PEOPLE
Eric Smith Lab for Synthetic Biology and Cellular Engineering
Eric Smith Lab for Synthetic Biology and Cellular Engineering
Eric Smith, MD PhD
|
Cedric Louvet, PhDInstructorCedric Louvet earned his PhD in Immunology in 2004 at the University of Nantes, France. During his thesis work he identified and studied genes linked to allograft rejection and tolerance with the aim to reveal novel mechanisms of immunoregulation. He joined the Jeff Bluestone lab at UCSF (2005-2009) for his postdoc to focus on clinically relevant genetically-modified mouse models of autoimmune diseases (type 1 diabetes and peripheral/central neuropathies) and developed a strong interest in T cell regulation and in the therapeutic potential of their manipulation. Back in France, he developed a basic science project aiming at elucidating the role of novel ion channels in the RORgt+ family including Th17/ILC3s (type 3 immunity) as well as in the regulation of antigen presentation to T cells by dendritic cells. More recently, he is translating his expertise in basic immunology into the emerging field of anti-tumor T-cell therapy to investigate original gene-engineering approaches for the immunotherapy of cancer.
|
Tim Haggerty, PhDLab Manager/Senior ScientistTim graduated with a Bachelor of Science in Molecular Genetics from the University of Rochester. Tim then went on to earn his PhD from Brandeis University studying Molecular and Cellular Biology. He has a broad background working on cancer immunotherapy, autoimmune disease, and cancer. He has worked at small start up companies with less than 10 people, big pharmaceutical companies, and medium sized biotechnology companies. With over 30 years of experience as a bench scientist he has expertise in molecular biology, drug discovery (both small molecule and biologics), target discovery and validation, phenotypic screens, and cell biology assay development. Tim has a passion for cancer immunotherapy with experience in genetic engineering of T cells to express transgenic TCRs and CARs to recognize kill cancer cells. All of his experience has been in preclinical research and therapeutic discovery and development.
|
Kartika Venugopal , PhDPost-doctoral fellowKartika earned her master’s degree in 2014 at the University of California, Irvine where she identified novel protein interaction partners for a serine-threonine death receptor kinase, DRAK2, and elucidated its role in immunological tolerance and autoimmunity. She then pursued a Ph.D. at the University of Florida, where her thesis work focused on understanding DNA methyltransferase 3A (DNMT3A; an epigenetic modifier gene) mutations as a biomarker for enhanced response to anti-leukemic therapy and investigated its methylation independent function in preserving genome integrity during DNA replication and repair.
|
Doug RussoDouglas holds a B.S. in Mathematics and Physics from Northeastern University and an M.S. in Statistics from Stanford University. His graduate research examined ancestry-specific effects among COVID-19 patients and the movement and admixture of Oceanic populations throughout history. His interests are in applied statistics and statistical learning for high dimensional and genomic data.
|
Elliott BreaFellowElliott Brea earned his B.S. in Biochemistry and University of Illinois Urbana Champaign. He earned his MD and PhD at Weill Cornell Medical College where he joined David Scheinberg’s lab at Sloan-Kettering Institute investigating regulators of MHC-I and antigen presentation in tumors, along with development of TCR mimetic antibodies. He then went on to do his residency at Brigham and Women’s Hospital where he short tracked and is current a hematology/oncology fellow at Dana-Farber Cancer Institute. He is interested in developing CAR-T for lung cancer and other solid tumors along with strategies to identify novel targets for solid tumor CAR-T therapy. In his free time he enjoys running, exploring new places, eating good pizza, and bread making.
|
Erin RosenbergResearch AssociateErin graduated from Villanova University with a B.S. in Biology and Cultural Studies. At Villanova, she completed an undergraduate thesis in the lab of Dr. Elaine Youngman, where she studied the regulation of Argonaute protein expression in C. elegans. After graduating, she moved to Philadelphia and continued to explore her interest in science and medicine. She worked in drug discovery for several years, both at GlaxoSmithKline (small molecule) and Integral Molecular (biologics). These experiences inspired her to continue her education at Boston University, where she is pursuing a M.S. in Medical Sciences. Outside of the lab, she enjoys running, hiking, and exploring Boston.
|
Elizabeth Carstens, MD
Fellow
Liz earned a BS in Bioengineering from Rice University in Houston, TX. Afterward she went to University of Texas Southwestern Medical Center for her MD which she earned with Distinction in Research for work she completed at the National Institutes of Health with Adrian Wiestner MD PhD designing complement targeting antibodies. She then completed residency in Internal Medicine at the Johns Hopkins Hospital and now is at Dana Farber as a hematology/oncology fellow. Her scientific interest is in nucleic acid based immunotherapies in solid malignancies. She also enjoys backpacking, fly fishing and crafts.
|
Carlos Fernandez (MSKCC)
Yunxin Chen (MSKCC) Urvi Shah (MSKCC) Mette Staehr (MSKCC) Reed Masakayan (MSKCC) Ishan Tatake (MSKCC) Abdulla Berjis(DFCI) |
Principal Investigator; Clinic Barcelona, IDIBAPS; lab page
Instructor; Singapore General Hospital, Duke-NUS Medical School Assistant Professor; Memorial Sloan Kettering Cancer Center Postdoctoral Research Fellow; University of Southern Denmark Associate Scientist; AgenTus Therapeutics Internal Medicine Resident; Beth Israel Deaconess Medical Center, Harvard Medical School PhD Student; University of Pennsylvania |